Tanner Smith and Andre Young scored 13 points each as Clemson pulled away from Virginia in the second half at Littlejohn Coliseum on Tuesday.
After a scoreless first half Devin Booker added 10 points and Milton Jennings led the Tigers with 8 rebounds.
For the second straight game Devin Coleman scored 9 off the bench for the Tigers.
Turnovers were huge in this game as Virginia committed 18 while Clemson only turned the ball over 9 times.
In addition, the Cavaliers only shot 1 free throw compared to 13 for Clemson.
